![]() ![]() In this way, it would be possible to help pathologists improve in terms of time and efficiency, as well as reduce the level of discordance that exists between them when trying to classify a given specimen.īiomedical and telecommunications engineers collaborate in the CVBLab group working on the implementation of computational techniques based on Machine Learning and Deep Learning applied to biomedical images, in order to find characteristics and patterns that allow to determine automatically not only if the patient has cancer, but also the type of malignant neoplasm. For this reason, AI4SKIN was born as a project whose main objective is to design and develop a diagnostic aid system to automatically classify biopsy samples from the 7 most common spindle cell neoplasms: leiomyoma, dermatofibroma, atypical fibroxanthoma (AFX), leiomyosarcoma, dermatofibrosarcoma protuberans (DFSP), squamous cell carcinoma and spindle cell melanoma. Spindle to stellate cells are embedded in a loose stroma compare with densely organized spindle. This fact hinders an accurate diagnosis and the application of effective clinical treatment in neoplasms in which early detection and appropriate treatment are essential for a good prognosis in malignant cases. 34.22 Amelanotic spindle cell dermal melanoma in a dog. However, cutaneous spindle cell neoplasms are difficult to diagnose due to the considerable morphological overlap between the different tumor types that make up this group, which poses a particular problem for less experienced pathologists. Their diagnosis is made by analysis of biopsied specimens by pathologists. Among the most common skin cancers are skin lesions composed predominantly of spindle cells, a heterogeneous group of skin tumors ranging from benign to malignant. Spindle cell melanoma (the cells are longer and tapered at the ends) Epithelioid melanoma (the cells are oval-shaped) Mixed cell melanoma (both spindle and epithelioid) Generally, a tumor made up of spindle cells has a better prognosis than a tumor made up of epithelioid cells. In fact, currently, one in three cancers diagnosed is skin cancer. The skin cancer incidence rate, melanoma and non-melanoma, is increasing worldwide. Spindle cell melanoma: Incidence and survival, 1973-2017 Authors Zhe Xu 1, Ping Shi 1, Feiluore Yibulayin 2 3, Lei Feng 2 4, Hao Zhang 4 5, Alimujiang Wushou 2 4 Affiliations 1 Department of Stomatology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong 518110, P.R. Spindle cell tumors have a better prognosis than those with epithelioid, mixed, or necrotic cells. 2001 Mar 44(3):451–455.Skin cancer represents the most common group of malignancies in the Caucasian population. Subcategories of tumors are spindle cell nevus, spindle cell melanoma, mixed cell melanoma, and mixed spindle and epithelioid. Evaluation of sentinel lymph node status in spindle cell melanomas. Thelmo MC, Sagebiel RW, Treseler PA, Morita ET, Nguyen LH, Kashani-Sabet M, Leong SP. HMB45 negative spindle cell malignant melanoma. Skelton HG, Maceira J, Smith KJ, McCarthy WF, Lupton GP, Graham JH. Melan-A/Mart-1 expression in various melanocytic lesions and in non-melanocytic soft tissue tumours. ![]() Biopsy pathology of melanocytic disorders. A case of amelanotic spindle-cell melanoma presenting as metastases to breast and axillary lymph node: diagnosis by FN A cytology. Squamous cell carcinoma detected by high-molecular-weight cytoheratin immunostaining mimicking atypical fibroxanthoma. Gray Y, Robidoux HJ, Farrell DS, Robinson-Bostom L. Individualized prognosis for melanoma patients. Philadelphia.Ĭochran AJ, Elashoff D, Morton DL, Elashoff R. Nerve infiltration or neurotropism is found in about half of desmoplastic melanomas. There is overlying melanoma in-situ, typically of lentigo maligna type, in approximately 75 of cases. Poorly differentiated, spindle cell malignancies, on sun damaged skin frequently pose a diagnostic challenge for pathologists. Carlson JA, Ackerman AB, Fletcher CD, Zeiger B. 67 genes co-occuring with the disease malignant spindle cell melanoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease. A paucicellular atypical spindle cell proliferation, separated by fibrocollagenous stroma within the dermis or subcutaneous fat. ![]()
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